COPS5 抗体 (AA 1-334)
Quick Overview for COPS5 抗体 (AA 1-334) (ABIN190283)
抗原
See all COPS5 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-334
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原理
- Anti-JAB-1 Mouse Monoclonal Antibody
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特异性
- This antibody recognizes human and mouse JAB-1.
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交叉反应
- 人, 小鼠
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免疫原
- Mouse JAB-1 gst-fusion protein (aa 1-334) expressed in E. coli.
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亚型
- IgG2a
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anti-COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5) antibody
COPS5 适用: 人 WB, IHC, IF, ChIP 宿主: 兔 Monoclonal unconjugated
anti-COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5) (AA 1-334) antibodyCOPS5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5) (AA 1-334) antibodyCOPS5 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5) antibodyCOPS5 适用: 人, 小鼠 WB, IHC, IHC (p), IP 宿主: 小鼠 Monoclonal 8H8-5 unconjugated
anti-COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5) antibodyCOPS5 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5) (Internal Region) antibodyCOPS5 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5) (AA 8-334) antibodyCOPS5 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC, IHC (fro), FACS 宿主: 兔 Polyclonal unconjugated
anti-COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5) antibodyCOPS5 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5) (Internal Region) antibodyCOPS5 适用: 人 WB, IHC, IHC (p), IP 宿主: 小鼠 Monoclonal unconjugated
anti-COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5) (N-Term) antibodyCOPS5 适用: 人, 小鼠, 大鼠, Pig, 马, 豚鼠, 兔 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Immunoblotting and
Immunoprecipitation: use at 0.5-1 μg/mL.
Positive controls: 293 cells and recombinant fusion protein. -
限制
- 仅限研究用
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状态
- Liquid
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溶解方式
- Dilute in PBS or medium which is identical to that used in the assay system.
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浓度
- Lot specific
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缓冲液
- PBS, pH 7.4
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储存条件
- -20 °C
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储存方法
- This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.
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- COPS5 (COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5))
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别名
- COPS5
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背景
- COP9 signalosome complex subunit 5,Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2. {PubMed:11285227, PubMed:11337588, PubMed:12628923, PubMed:12732143, PubMed:19214193, PubMed:20978819, PubMed:22609399, PubMed:9535219}.,JAB-1 is a 38 kD protein which was originally described as a coactivator for cJUN. It is present in a large protein complex called the â€signalosome†which has been proposed to play a signaling role in mammalian cells. This protein complex appears to be analogous to the COP9 complex in plants which plays an important role in light-mediated plant development. Although the specific function of JAB-1 is unclear, it appears to be involved in targeting proteins for degradation by the proteasome.,Cytoplasm, cytosol, Nucleus, Cytoplasm, perinuclear region, Cytoplasmic vesicle, secretory vesicle, synaptic vesicle,SGN5, Signalosome subunit 5, EC 3.4.-.-, Jun activation domain-binding protein 1
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UniProt
- Q92905
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途径
- Cell Division Cycle
抗原
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