ESR2 抗体 (AA 1-153)
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Quick Overview for ESR2 抗体 (AA 1-153) (ABIN189996)
抗原
See all ESR2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-153
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原理
- Anti-Estrogen Receptor beta Mouse Monoclonal Antibody
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特异性
- This antibody recognizes human ER-b, a novel receptor (approx. 52 kD) recently isolated from testis. The size and structure of ER-b are very similar to ER-alpha with the ligand and DNA binding domains being highly conserved. The N-terminus of each receptor, which serves as their transactivation domain, are significantly different. Like ER-alpha, ER-b binds to estrogen with a high affinity and regulates estrogen-specific gene activation through direct interaction with estrogen response elements.
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交叉反应
- 人
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免疫原
- 6-His fusion protein containing the region encoding aa 1-153 of human estrogen receptor-b (ER-b) expressed in E. coli.
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亚型
- IgG2b
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anti-Estrogen Receptor 2 (ESR2) (C-Term) antibody
ESR2 适用: 人 WB, IHC, IF, FACS 宿主: 小鼠 Monoclonal ERb455 unconjugated
anti-Estrogen Receptor 2 (ESR2) (N-Term) antibodyESR2 适用: 人, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Estrogen Receptor 2 (ESR2) (C-Term) antibodyESR2 适用: 人, 小鼠, 大鼠, 绵羊, Pig, 马, 猴 WB, IF, FACS, IHC (p) 宿主: 小鼠 Monoclonal ERb455 unconjugated
anti-Estrogen Receptor 2 (ESR2) (AA 201-300) antibodyESR2 适用: 人, 小鼠, 大鼠, 绵羊 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Estrogen Receptor 2 (ESR2) (AA 211-240) antibodyESR2 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB41114 unconjugated
anti-Estrogen Receptor 2 (ESR2) (AA 46-530) antibodyESR2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Estrogen Receptor 2 (ESR2) (AA 417-428) antibodyVerified ESR2 适用: 人 WB, ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Estrogen Receptor 2 (ESR2) (AA 1-280) antibodyESR2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Estrogen Receptor 2 (ESR2) (pSer105) antibodyESR2 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Estrogen Receptor 2 (ESR2) (AA 22-121) antibodyESR2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3F3 unconjugated
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应用备注
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Immunoblotting: use at 1-5 μg/mL.
Positive controls: Native receptor from human thymus, spleen, ovary, and testis or recombinant protein. -
限制
- 仅限研究用
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状态
- Liquid
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溶解方式
- Dilute in PBS or medium which is identical to that used in the assay system.
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浓度
- Lot specific
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缓冲液
- PBS, pH 7.4
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储存条件
- -80 °C
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储存方法
- This antibody is stable for at least one (1) year at -70°C. Avoid multiple freeze- thaw cycles.
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- ESR2 (Estrogen Receptor 2 (ESR2))
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别名
- Estrogen receptor beta
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背景
- Estrogen receptor beta,Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). {PubMed:20074560, PubMed:29261182, PubMed:30113650, PubMed:9325313}., [Isoform 2]: Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability. {PubMed:9671811}.,Nucleus,ER-beta, Nuclear receptor subfamily 3 group A member 2
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基因ID
- 2100
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NCBI登录号
- NP_001035365
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UniProt
- Q92731
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途径
- Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling
抗原
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