Exportin 2 抗体
Quick Overview for Exportin 2 抗体 (ABIN6571992)
抗原
See all Exportin 2 (CSE1L) 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- Affinity purification
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免疫原
- A synthetic peptide of human CSE1L
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- Exportin 2 (CSE1L) (CSE1 Chromosome Segregation 1-Like (CSE1L))
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别名
- CSE1L
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背景
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Synonyms: CAS,Cellular apoptosis susceptibility protein,Chromosome segregation 1 (yeast homolog) like,Chromosome segregation 1 Like,Chromosome segregation 1 like protein,Chromosome segregation 1-like protein,Chromosome segregation gene CSE1,CSE 1,CSE 1 chromosome segregation 1 like,CSE 1 chromosome segregation 1 like protein,CSE 1L,CSE1,CSE1 chromosome segregation 1 like (yeast),CSE1 chromosome segregation 1 like,CSE1 chromosome segregation 1 like protein,CSE1L,Exp 2,Exp2,Exportin 2,Exportin-2,Exportin2,Importin alpha re exporter,Importin-alpha re-exporter,MGC117283,MGC130036,MGC130037,XPO 2,XPO2,XPO2
Background: Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene.
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分子量
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Observed_MW: 110kDa
Calculated_MW: 22kDa/103kDa/107kDa/110kDa
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基因ID
- 1434
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UniProt
- P55060
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途径
- Protein targeting to Nucleus
抗原
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