Androgen Receptor 抗体 (Center)
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- 抗原 See all Androgen Receptor (AR) 抗体
- Androgen Receptor (AR)
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抗原表位
- AA 282-309, Center
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Androgen Receptor antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 特异性
- This AR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 281-309 amino acids from the Central region of human AR.
- 预测反应
- Monkey
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This AR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 282-309 AA from the Central region of human AR.
- 克隆位点
- RB32967
- 亚型
- Ig Fraction
- Top Product
- Discover our top product AR Primary Antibody
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- 应用备注
- WB = 1:1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.33 mg/mL
- 缓冲液
- PBS with 0.09 % (W/V) sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- AR Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
- 有效期
- 6 months
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- 抗原
- Androgen Receptor (AR)
- 别名
- AR (AR 产品)
- 别名
- AIS antibody, DHTR antibody, HUMARA antibody, HYSP1 antibody, KD antibody, NR3C4 antibody, SBMA antibody, SMAX1 antibody, TFM antibody, AW320017 antibody, Tfm antibody, Andr antibody, AR antibody, androgen receptor antibody, AR antibody, Ar antibody, ar antibody
- 背景
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The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq].
Synonyms: Androgen receptor,AR,DHTR, NR3C4 - 分子量
- 98989 DA
- 基因ID
- 367
- NCBI登录号
- NP_001011645, NP_000035
- UniProt
- P10275
- 途径
- Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Chromatin Binding
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