EFCAB4B 抗体
Quick Overview for EFCAB4B 抗体 (ABIN6568176)
抗原
See all EFCAB4B 抗体适用
宿主
克隆类型
标记
应用范围
-
-
纯化方法
- Affinity purification
-
免疫原
- Recombinant fusion protein of human CRACR2A (NP_001138430.1).
-
亚型
- IgG
-
-
anti-EF-Hand Calcium Binding Domain 4B (EFCAB4B) (AA 1-200) antibody
EFCAB4B 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-EF-Hand Calcium Binding Domain 4B (EFCAB4B) (AA 1-395) antibodyEFCAB4B 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-EF-Hand Calcium Binding Domain 4B (EFCAB4B) (AA 215-264) antibodyEFCAB4B 适用: 人, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-EF-Hand Calcium Binding Domain 4B (EFCAB4B) (AA 71-120) antibodyEFCAB4B 适用: 人, 马, 大鼠, Cow, 犬, 豚鼠, 兔 WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- WB 1:500-1:2000 IHC 1:50-1:200
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
-
-
- EFCAB4B (EF-Hand Calcium Binding Domain 4B (EFCAB4B))
-
别名
- CRACR2A
-
背景
- Ca2+-binding protein that plays a key role in store-operated Ca2+entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca2+resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
-
分子量
-
Observed_MW: 45kDa
Calculated_MW: 45kDa/83kDa
-
基因ID
- 84766
-
UniProt
- Q9BSW2
抗原
-
