GEN1 抗体
Quick Overview for GEN1 抗体 (ABIN6566734)
抗原
See all GEN1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
纯化方法
- Affinity purification
-
免疫原
- Recombinant protein of human GEN1
-
亚型
- IgG
-
-
anti-Gen Endonuclease Homolog 1 (GEN1) (AA 669-908) antibody
GEN1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Gen Endonuclease Homolog 1 (GEN1) (AA 60-89), (N-Term) antibodyGEN1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB23975 unconjugated
-
-
应用备注
- WB 1:500 - 1:2000
-
限制
- 仅限研究用
-
-
-
浓度
- 1 mg/mL
-
缓冲液
- Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
-
-
- GEN1 (Gen Endonuclease Homolog 1 (GEN1))
-
别名
- GEN1
-
背景
-
Synonyms: DKFZp781F0986,Flap endonuclease GEN homolog 1,FLJ40869,GEN 1,Gen,Gen homolog 1 endonuclease (Drosophila),Gen homolog 1 endonuclease,GEN,GEN1
Background: This gene encodes a member of the Rad2/xeroderma pigmentosum group G nuclease family, whose members are characterized by N-terminal and internal xeroderma pigmentosum group G nuclease domains followed by helix-hairpin-helix domains and disordered C-terminal domains. The protein encoded by this gene is involved in resolution of Holliday junctions, which are intermediate four-way structures that covalently link DNA during homologous recombination and double-strand break repair. The protein resolves Holliday junctions by creating dual incisions across the junction to produce nicked duplex products that can be ligated. In addition, this protein has been found to localize to centrosomes where it has been implicated in regulation of centrosome integrity. Alternative splicing results in multiple transcript variants.
-
分子量
-
Observed_MW: 103kDa
Calculated_MW: 102kDa
-
基因ID
- 348654
-
UniProt
- Q17RS7
-
途径
- DNA Damage Repair
抗原
-
