PDP 抗体 (AA 308-336)
(1 reference)Quick Overview for PDP 抗体 (AA 308-336) (ABIN656386)
抗原
See all PDP 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 308-336
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This PDP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-336 amino acids from the Central region of human PDP1.
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亚型
- Ig Fraction
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anti-Pyruvate Dehydrogenase Phosphatase (PDP) (AA 278-537) antibody
PDP 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Pyruvate Dehydrogenase Phosphatase (PDP) (AA 1-154) antibodyPDP 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Pyruvate Dehydrogenase Phosphatase (PDP) antibodyPDP 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Pyruvate Dehydrogenase Phosphatase (PDP) (AA 72-260) antibodyPDP 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Pyruvate Dehydrogenase Phosphatase (PDP) (AA 315-537) antibodyPDP 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Pyruvate Dehydrogenase Phosphatase (PDP) (AA 366-395), (Middle Region) antibodyPDP 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Pyruvate Dehydrogenase Phosphatase (PDP) (AA 821-850), (C-Term) antibodyPDP 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:1000. WB: 1:2000. IHC-P: 1:10~50
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- PDP1 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
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有效期
- 6 months
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: "Tyr-94 phosphorylation inhibits pyruvate dehydrogenase phosphatase 1 and promotes tumor growth." in: The Journal of biological chemistry, Vol. 289, Issue 31, pp. 21413-22, (2014) (PubMed).
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: "Tyr-94 phosphorylation inhibits pyruvate dehydrogenase phosphatase 1 and promotes tumor growth." in: The Journal of biological chemistry, Vol. 289, Issue 31, pp. 21413-22, (2014) (PubMed).
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- PDP (Pyruvate Dehydrogenase Phosphatase (PDP))
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别名
- PDP1
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背景
- Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported, one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
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分子量
- 61054
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基因ID
- 54704
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NCBI登录号
- NP_001155251, NP_001155252, NP_001155253, NP_060914
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UniProt
- Q9P0J1
抗原
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