DVL1 抗体 (AA 442-470)
Quick Overview for DVL1 抗体 (AA 442-470) (ABIN656260)
抗原
See all DVL1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 442-470
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预测反应
- Rat
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This DVL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 442-470 amino acids from the Central region of human DVL1.
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亚型
- Ig Fraction
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应用备注
- IF: 1:10~50. IF: 1:25. WB: 1:1000. WB: 1:2000. WB: 1:1000. IHC-P: 1:10~50. IHC-P: 1:25
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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有效期
- 6 months
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: "Mutations in DVL1 cause an osteosclerotic form of Robinow syndrome." in: American journal of human genetics, Vol. 96, Issue 4, pp. 623-30, (2015) (PubMed).
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: "Mutations in DVL1 cause an osteosclerotic form of Robinow syndrome." in: American journal of human genetics, Vol. 96, Issue 4, pp. 623-30, (2015) (PubMed).
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- DVL1 (Dishevelled Segment Polarity Protein 1 (DVL1))
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别名
- DVL1
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背景
- DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development.
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分子量
- 75187
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基因ID
- 1855
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NCBI登录号
- NP_004412
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UniProt
- O14640
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途径
- WNT signaling, Synaptic Membrane, Skeletal Muscle Fiber Development
抗原
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