GNAT3 抗体 (AA 78-105)
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北京 101111
Quick Overview for GNAT3 抗体 (AA 78-105) (ABIN654441)
抗原
See all GNAT3 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 78-105
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This GNAT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 78-105 amino acids from the Central region of human GNAT3.
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亚型
- Ig Fraction
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anti-Guanine Nucleotide Binding Protein, alpha Transducing 3 (GNAT3) antibody
GNAT3 适用: 人, 小鼠, 大鼠 ELISA, IHC, WB 宿主: 兔 Polyclonal unconjugated
anti-Guanine Nucleotide Binding Protein, alpha Transducing 3 (GNAT3) (AA 60-130) antibodyGNAT3 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Guanine Nucleotide Binding Protein, alpha Transducing 3 (GNAT3) (AA 2-354) antibodyGNAT3 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Guanine Nucleotide Binding Protein, alpha Transducing 3 (GNAT3) (AA 85-113), (Middle Region) antibodyGNAT3 适用: 人 WB, FACS, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Guanine Nucleotide Binding Protein, alpha Transducing 3 (GNAT3) (Internal Region) antibodyVerified GNAT3 适用: 人 ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
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应用备注
- WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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有效期
- 6 months
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- GNAT3 (Guanine Nucleotide Binding Protein, alpha Transducing 3 (GNAT3))
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别名
- GNAT3
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背景
- Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase, Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium. GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors. Functions also as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity.
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分子量
- 40357
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基因ID
- 346562
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NCBI登录号
- NP_001095856
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UniProt
- A8MTJ3
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途径
- Peptide Hormone Metabolism, G-protein mediated Events, Phototransduction
抗原
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