GNAT3 抗体 (Middle Region)
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- 抗原 See all GNAT3 抗体
- GNAT3 (Guanine Nucleotide Binding Protein, alpha Transducing 3 (GNAT3))
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抗原表位
- AA 85-113, Middle Region
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This GNAT3 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
- 特异性
- This antibody recognizes Human GNAT3 (Center).
- 纯化方法
- Protein A column, followed by peptide affinity purification
- 免疫原
- KLH conjugated synthetic peptide between 85-113 amino acids from the Central region of Human GNAT3
- 亚型
- Ig Fraction
- Top Product
- Discover our top product GNAT3 Primary Antibody
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anti-Guanine Nucleotide Binding Protein, alpha Transducing 3 (GNAT3) antibody
GNAT3 适用: 人, 小鼠, 大鼠 ELISA, IHC, WB 宿主: 兔 Polyclonal unconjugated
anti-Guanine Nucleotide Binding Protein, alpha Transducing 3 (GNAT3) (AA 2-354) antibodyGNAT3 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Guanine Nucleotide Binding Protein, alpha Transducing 3 (GNAT3) (AA 60-130) antibodyGNAT3 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Guanine Nucleotide Binding Protein, alpha Transducing 3 (GNAT3) (AA 78-105) antibodyGNAT3 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB24621 unconjugated
anti-Guanine Nucleotide Binding Protein, alpha Transducing 3 (GNAT3) (Internal Region) antibodyVerified GNAT3 适用: 人 ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.25 mg/mL
- 缓冲液
- PBS containing 0.09 % (W/V) Sodium Azide as preservative
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- 抗原
- GNAT3 (Guanine Nucleotide Binding Protein, alpha Transducing 3 (GNAT3))
- 别名
- GNAT3 (GNAT3 产品)
- 别名
- GDCA antibody, Ggust antibody, Gtn antibody, gnat-3 antibody, G protein subunit alpha transducin 3 antibody, guanine nucleotide binding protein, alpha transducing 3 antibody, GNAT3 antibody, Gnat3 antibody
- 背景
- Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase, Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium. GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors. Functions also as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity.Synonyms: G protein G(t) subunit alpha-3, Guanine nucleotide-binding protein G(t) subunit alpha-3, Gustducin alpha-3 chain
- 分子量
- 40357 Da
- 基因ID
- 346562
- NCBI登录号
- NP_001095856
- 途径
- Peptide Hormone Metabolism, G-protein mediated Events, Phototransduction
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