STIM1 抗体 (C-Term)
Quick Overview for STIM1 抗体 (C-Term) (ABIN654073)
抗原
See all STIM1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 509-538, C-Term
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预测反应
- M
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This STIM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 509-538 amino acids from the C-terminal region of human STIM1.
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亚型
- Ig Fraction
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应用备注
- WB: 1:1000. IHC-P: 1:50~100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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有效期
- 6 months
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Suppression of STIM1 inhibits the migration and invasion of human prostate cancer cells and is associated with PI3K/Akt signaling inactivation." in: Oncology reports, Vol. 38, Issue 5, pp. 2629-2636, (2018) (PubMed).
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Suppression of STIM1 inhibits the migration and invasion of human prostate cancer cells and is associated with PI3K/Akt signaling inactivation." in: Oncology reports, Vol. 38, Issue 5, pp. 2629-2636, (2018) (PubMed).
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- STIM1 (Stromal Interaction Molecule 1 (STIM1))
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别名
- STIM1
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背景
- This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene.
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分子量
- 77423
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基因ID
- 6786
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NCBI登录号
- NP_001264891, NP_003147
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UniProt
- Q13586
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途径
- TCR Signaling, BCR Signaling
抗原
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