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CHMP4B 抗体 (N-Term)

This anti-CHMP4B antibody is a 兔 多克隆 antibody detecting CHMP4B in WB, FACS 和 IHC (p). Suitable for 人. This Primary Antibody has been cited in 1 publication.
产品编号 ABIN653481
发货至: 中国

Quick Overview for CHMP4B 抗体 (N-Term) (ABIN653481)

抗原

See all CHMP4B 抗体
CHMP4B (Charged Multivesicular Body Protein 4B (CHMP4B))

适用

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宿主

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克隆类型

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多克隆

标记

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This CHMP4B antibody is un-conjugated

应用范围

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Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB24088
  • 抗原表位

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    AA 51-79, N-Term

    预测反应

    C, Zf, M, X

    纯化方法

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    免疫原

    This CHMP4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51-79 amino acids from the N-terminal region of human CHMP4B.

    亚型

    Ig Fraction
  • 应用备注

    WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    有效期

    6 months
  • Hu, Jiang, Chen, Wei, Zhang, Zhao, Ni, Lu, Wan: "High CHMP4B expression is associated with accelerated cell proliferation and resistance to doxorubicin in hepatocellular carcinoma." in: Tumour biology, Vol. 36, Issue 4, pp. 2569-81, (2015) (PubMed).

  • 抗原

    CHMP4B (Charged Multivesicular Body Protein 4B (CHMP4B))

    别名

    CHMP4B

    背景

    CHMP4B is a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies.

    分子量

    24950

    基因ID

    128866

    NCBI登录号

    NP_789782

    UniProt

    Q9H444
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