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LMX1B 抗体 (AA 175-202)

This anti-LMX1B antibody is a 兔 多克隆 antibody detecting LMX1B in WB 和 IHC (p). Suitable for 人 和 小鼠. This Primary Antibody has been cited in 2+ publications.
产品编号 ABIN652882
发货至: 中国

Quick Overview for LMX1B 抗体 (AA 175-202) (ABIN652882)

抗原

See all LMX1B 抗体
LMX1B (LIM Homeobox Transcription Factor 1, beta (LMX1B))

适用

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人, 小鼠

宿主

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克隆类型

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多克隆

标记

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This LMX1B antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB21468
  • 抗原表位

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    AA 175-202

    预测反应

    C, X

    纯化方法

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    免疫原

    This LMX1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 175-202 amino acids from the Central region of human LMX1B.

    亚型

    Ig Fraction
  • 应用备注

    WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    有效期

    6 months
  • Doucet-Beaupré, Gilbert, Profes, Chabrat, Pacelli, Giguère, Rioux, Charest, Deng, Laguna, Ericson, Perlmann, Ang, Cicchetti, Parent, Trudeau, Lévesque: "Lmx1a and Lmx1b regulate mitochondrial functions and survival of adult midbrain dopaminergic neurons." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, Issue 30, pp. E4387-96, (2018) (PubMed).

    Laguna, Schintu, Nobre, Alvarsson, Volakakis, Jacobsen, Gómez-Galán, Sopova, Joodmardi, Yoshitake, Deng, Kehr, Ericson, Svenningsson, Shupliakov, Perlmann: "Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease." in: Nature neuroscience, Vol. 18, Issue 6, pp. 826-35, (2015) (PubMed).

  • 抗原

    LMX1B (LIM Homeobox Transcription Factor 1, beta (LMX1B))

    别名

    LMX1B

    背景

    LMX1B is required for the normal development of the dopaminergic system. Loss of dopaminergic neurons is associated with one of the most prominent human neurological disorders, Parkinson's disease (PD). Dopaminergic neurons play an important role in the control of multiple brain functions including voluntary movement alongside an array of behavioral processes such as mood, reward, addiction, and stress. Lmx1b is one of several transcription factors involved in the generation of dopaminergic neurons in the brain.

    分子量

    44917

    基因ID

    4010

    NCBI登录号

    NP_001167618, NP_002307

    UniProt

    O60663

    途径

    Dopaminergic Neurogenesis
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