DERL1 抗体 (C-Term)
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Quick Overview for DERL1 抗体 (C-Term) (ABIN652693)
抗原
See all DERL1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 224-251, C-Term
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预测反应
- B
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This DERL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 224-251 amino acids from the C-terminal region of human DERL1.
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亚型
- Ig Fraction
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anti-Der1-Like Domain Family, Member 1 (DERL1) (AA 111-220) antibody
DERL1 适用: 人 ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Der1-Like Domain Family, Member 1 (DERL1) (AA 224-251) antibodyDERL1 适用: 人, 小鼠 WB, IHC, IHC (p), FACS 宿主: 兔 Polyclonal unconjugated
anti-Der1-Like Domain Family, Member 1 (DERL1) (AA 222-251), (C-Term) antibodyDERL1 适用: 人, 小鼠 WB, IHC (p), FACS, EIA 宿主: 兔 Polyclonal unconjugated
anti-Der1-Like Domain Family, Member 1 (DERL1) (AA 200-251), (C-Term) antibodyDERL1 适用: 人, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:16000. WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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有效期
- 6 months
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- DERL1 (Der1-Like Domain Family, Member 1 (DERL1))
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别名
- DERL1
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背景
- Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. DERL1 may act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. It may mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.
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分子量
- 28801
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基因ID
- 79139
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NCBI登录号
- NP_001128143, NP_077271
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UniProt
- Q9BUN8
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途径
- ER-Nucleus Signaling
抗原
-
