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DERL1 抗体 (AA 111-220) (HRP)

The 兔 多克隆 anti-DERL1 antibody is suitable to detect DERL1 in samples from 人. It has been validated for ELISA, IHC (p) 和 IHC (fro).
产品编号 ABIN1408154
发货至: 中国
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Quick Overview for DERL1 抗体 (AA 111-220) (HRP) (ABIN1408154)

抗原

See all DERL1 抗体
DERL1 (Der1-Like Domain Family, Member 1 (DERL1))

适用

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宿主

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克隆类型

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多克隆

标记

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This DERL1 antibody is conjugated to HRP

应用范围

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ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • 抗原表位

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    AA 111-220

    交叉反应

    预测反应

    Mouse,Rat,Dog,Cow,Sheep,Horse,Rabbit

    纯化方法

    Purified by Protein A.

    免疫原

    KLH conjugated synthetic peptide derived from human DERLIN-1

    亚型

    IgG
  • 应用备注

    IHC-P 1:200-400
    IHC-F 1:100-500

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    注意事项

    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    有效期

    12 months
  • 抗原

    DERL1 (Der1-Like Domain Family, Member 1 (DERL1))

    别名

    DERLIN-1

    背景

    Synonyms: Derlin1, Derlin1, Derlin 1, DER1, DER-1, DER 1, DERL1_HUMAN.

    Background: Degradation in endoplasmic reticulum proteins, also designated Derlins or DERtrins, are crucial for the degradation of misfolded endoplasmic reticulum (ER) luminal proteins. Derlin proteins are multi-pass membrane proteins localizing to the ER. Derlins are involved in transferring misfolded proteins from the ER to the cytosol, where the misfolded proteins are destroyed in an ubiquitin-dependent manner by the proteasome. In the case of cytomegalovirus infection, Derlin-1, as opposed to Derlins-2 and -3, is involved in the export of MHC class I heavy chains from the ER via its interaction with the viral protein US11. Derlins may also be important for cell proliferation.

    基因ID

    79139

    UniProt

    Q9BUN8

    途径

    ER-Nucleus Signaling
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