PHD1 抗体 (AA 194-221)
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北京 101111
Quick Overview for PHD1 抗体 (AA 194-221) (ABIN652648)
抗原
See all PHD1 (EGLN2) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 194-221
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This EGLN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 194-221 amino acids from the Central region of human EGLN2.
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亚型
- Ig Fraction
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应用备注
- WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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有效期
- 6 months
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- PHD1 (EGLN2) (Egl-9 Family Hypoxia Inducible Factor 2 (EGLN2))
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别名
- EGLN2
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背景
- EGLN2 catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF-1 alpha at 'Pro-402' and 'Pro-564', and HIF-2 alpha. It functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. It may play a role in cell growth regulation.
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分子量
- 43650
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基因ID
- 112398
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NCBI登录号
- NP_444274, NP_542770
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UniProt
- Q96KS0
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Cell RedoxHomeostasis
抗原
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