BRISC and BRCA1 A Complex Member 1 (BABAM1) (AA 116-143) 抗体
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Quick Overview for BRISC and BRCA1 A Complex Member 1 (BABAM1) (AA 116-143) 抗体 (ABIN652514)
抗原
See all BRISC and BRCA1 A Complex Member 1 (BABAM1) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 116-143
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预测反应
- B, M, Rat
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纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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免疫原
- This HSPC142 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 116-143 amino acids from the Central region of human HSPC142.
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亚型
- Ig Fraction
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anti-BRISC and BRCA1 A Complex Member 1 (BABAM1) (AA 36-85) antibody
BABAM1 适用: 人, 小鼠, 犬, 豚鼠, 马, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-BRISC and BRCA1 A Complex Member 1 (BABAM1) (AA 1-329) antibodyBABAM1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-BRISC and BRCA1 A Complex Member 1 (BABAM1) (AA 9-37), (N-Term) antibodyBABAM1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB20467 unconjugated
anti-BRISC and BRCA1 A Complex Member 1 (BABAM1) (N-Term) antibodyBABAM1 适用: 人, 小鼠, 犬, 豚鼠, 马, 大鼠, Cow WB 宿主: 兔 Polyclonal unconjugated
anti-BRISC and BRCA1 A Complex Member 1 (BABAM1) (Middle Region) antibodyBABAM1 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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有效期
- 6 months
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- BRISC and BRCA1 A Complex Member 1 (BABAM1)
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别名
- HSPC142
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背景
- Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36. component.
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分子量
- 36560
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基因ID
- 29086
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NCBI登录号
- NP_001028721, NP_054892
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UniProt
- Q9NWV8
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途径
- Positive Regulation of Response to DNA Damage Stimulus
抗原
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