HAS2 抗体 (AA 138-166)
(2 references)Quick Overview for HAS2 抗体 (AA 138-166) (ABIN651874)
抗原
See all HAS2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 138-166
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This HAS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-166 amino acids of human HAS2.
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亚型
- IgG
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anti-Hyaluronan Synthase 2 (HAS2) (AA 67-170) antibody
HAS2 适用: 人 ELISA, WB, IHC, ICC 宿主: 小鼠 Monoclonal 4E7 unconjugated
anti-Hyaluronan Synthase 2 (HAS2) antibodyHAS2 适用: 人, 小鼠, 大鼠 WB, IF (p), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Hyaluronan Synthase 2 (HAS2) (AA 70-359) antibodyHAS2 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Hyaluronan Synthase 2 (HAS2) antibodyHAS2 适用: 人 ELISA, WB, IHC, IHC (p), IF 宿主: 小鼠 Monoclonal 40000000 unconjugated
anti-Hyaluronan Synthase 2 (HAS2) (AA 67-185) antibodyHAS2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:1000. IHC-P: 1:25. IHC-P: 1:50~100. FC: 1:10~50
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid freeze-thaw cycles.
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储存条件
- 4 °C,-20 °C
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储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
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有效期
- 6 months
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: "Differential expression of hyaluronan synthase 2 in breast carcinoma and its biological significance." in: Histopathology, Vol. 65, Issue 3, pp. 328-39, (2015) (PubMed).
: "Gene expression profile of a newly established choriocarcinoma cell line, iC3-1, compared to existing choriocarcinoma cell lines and normal placenta." in: Placenta, Vol. 34, Issue 2, pp. 110-8, (2013) (PubMed).
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: "Differential expression of hyaluronan synthase 2 in breast carcinoma and its biological significance." in: Histopathology, Vol. 65, Issue 3, pp. 328-39, (2015) (PubMed).
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- HAS2 (Hyaluronan Synthase 2 (HAS2))
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别名
- HAS2
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背景
- Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1.
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分子量
- 63566
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基因ID
- 3037
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NCBI登录号
- NP_005319
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UniProt
- Q92819
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途径
- Glycosaminoglycan Metabolic Process
抗原
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