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Caspase 3 抗体 (Cleaved-Asp175)

This anti-Caspase 3 antibody is a 兔 多克隆 antibody detecting Caspase 3 in IHC (p) 和 DB. Suitable for 人. This Primary Antibody has been cited in 2+ publications.
产品编号 ABIN650861
发货至: 中国

Quick Overview for Caspase 3 抗体 (Cleaved-Asp175) (ABIN650861)

抗原

See all Caspase 3 (CASP3) 抗体
Caspase 3 (CASP3)

适用

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宿主

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克隆类型

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多克隆

标记

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This Caspase 3 antibody is un-conjugated

应用范围

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Dot Blot (DB)

克隆位点

RB25833
  • 抗原表位

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    AA 149-175, Cleaved-Asp175

    预测反应

    B, M, Pig, Rat

    纯化方法

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    免疫原

    This Cleaved antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 149-175 amino acids from human Cleaved.

    亚型

    Ig Fraction
  • 应用备注

    IHC-P: 1:50~100. DB: 1:500

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    有效期

    6 months
  • Chen, Liu, Wei, Wu, Luo, Yuan, Luo, Chen: "The long noncoding RNA ASNR regulates degradation of Bcl-2 mRNA through its interaction with AUF1." in: Scientific reports, Vol. 6, pp. 32189, (2018) (PubMed).

    Luo, Sun, Wei, Luo, Yang, Liu, Guo, Chen: "Functional Characterization of Long Noncoding RNA Lnc_bc060912 in Human Lung Carcinoma Cells." in: Biochemistry, Vol. 54, Issue 18, pp. 2895-902, (2015) (PubMed).

  • 抗原

    Caspase 3 (CASP3)

    别名

    CASP3

    背景

    CASP3 encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.

    分子量

    31608

    基因ID

    836

    NCBI登录号

    NP_004337, NP_116786

    UniProt

    P42574

    途径

    Apoptosis, Caspase Cascade in Apoptosis, Sensory Perception of Sound, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation
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