MAP2 抗体 (pSer1539)
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Quick Overview for MAP2 抗体 (pSer1539) (ABIN650809)
抗原
See all MAP2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- pSer1539
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预测反应
- M, Rat
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This MAP2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1539 of human MAP2.
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亚型
- Ig Fraction
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应用备注
- DB: 1:500
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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有效期
- 6 months
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- MAP2 (Microtubule-Associated Protein 2 (MAP2))
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别名
- MAP2
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背景
- MAP2 is the major microtubule associated protein of brain tissue. There are three forms of MAP2, two are similarily sized with apparent molecular weights of 280 kDa (MAP2a and MAP2b) and the third with a lower molecular weight of 70 kDa (MAP2c). In the newborn rat brain, MAP2b and MAP2c are present, while MAP2a is absent. Between postnatal days 10 and 20, MAP2a appears. At the same time, the level of MAP2c drops by 10-fold. This change happens during the period when dendrite growth is completed and when neurons have reached their mature morphology. MAP2 is degraded by a Cathepsin D-like protease in the brain of aged rats. There is some indication that MAP2 is expressed at higher levels in some types of neurons than in other types. MAP2 is known to promote microtubule assembly and to form side-arms on microtubules. It also interacts with neurofilaments, actin, and other elements of the cytoskeleton.
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分子量
- 199526
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基因ID
- 4133
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NCBI登录号
- NP_001034627, NP_002365, NP_114033, NP_114035
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UniProt
- P11137
抗原
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