Caspase 7 抗体 (C-Term)
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北京 101111
Quick Overview for Caspase 7 抗体 (C-Term) (ABIN644997)
抗原
See all Caspase 7 (CASP7) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- Rabbit Anti-Human CASP7 (C-term)
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特异性
- DS-PB-00381 recognizes an epitope within the C-terminal region (CT) of Caspase7, a 35kDa cysteine protease, otherwise known as ICE like Apoptotic Protease 3 (ICELAP3). Caspase7, a member of the ICE/Ced3 subfamily, is an executioner caspase which undergoes proteolytic cleavage of its precursor to form active p12 and p20 subunits. Evidence that activation of Caspase7 occurs during cell death induced by the cytokine death receptors Fas/APO1 and the receptor of tumor necrosis factor (TNFR1), coupled with the fact that granzymeB activated Caspase7 cleaves the nuclear enzyme poly (ADPribose) polymerase (PARP), suggests an important role for Caspase7 in both cytokinemediated and GranzymeB mediated apoptosis pathways.
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交叉反应
- 小鼠, 大鼠
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产品特性
- Phosphorylation/Apoptosis/Signal Transduction/Regulation
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纯化方法
- Purified
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免疫原
- Antisera to human Caspase-7 (CT) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.
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亚型
- IgG
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应用备注
- Immunohistology - Paraffin, Western Blotting
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限制
- 仅限研究用
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浓度
- IgG concentration 1.0 mg/ml
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缓冲液
- Phosphate buffered saline
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- -20°C
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- Caspase 7 (CASP7) (Caspase 7, Apoptosis-Related Cysteine Peptidase (CASP7))
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别名
- Caspase-7
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途径
- Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity
抗原
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