Complement C4d 抗体
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北京 101111
Quick Overview for Complement C4d 抗体 (ABIN640791)
抗原
适用
宿主
克隆类型
标记
应用范围
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原理
- Mouse Anti-Human C4d
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特异性
- DS-MB-00163 recognizes the secreted protein complement component 4d (C4d). The complement 1 complex cleaves complement 4 (C4) to form C4b and C4a. C4b levels are strictly regulated. Single site cleavage of the C4b's alpha chain by Factor I forms iC4b and blocks C3 convertase, inhibiting opsonisation and activation of the classical pathway. This requires C4 binding protein or CR1 as a cofactor. iC4b is further degraded into C4d and C4c. C4d's short half life means that C4d is present in serum at high enough concentrations to make it a useful marker for classical complement activation. C4 has been linked to susceptibility to systemic lupus erythematosous. ImmunohistologyIt has been reported that this antibody works very well on acetone-fixed, frozen renal biopsies. Strong staining is observed in the glomeruli and in some cases the peritubular capillaries. DS-MB-00163 has given variable results on formalin-fixed, paraffin-embedded sections. It has been observed that pre-treatment with 88% formic acid for 20 minutes at room temperature is beneficial (6).
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产品特性
- Blood Coagulation Proteins
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纯化方法
- Purified
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免疫原
- Native, from human plasma
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亚型
- IgG1
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anti-Complement Component C4d (C4d) (Internal Region) antibody
C4d 适用: 人 IHC (p) 宿主: 兔 Monoclonal A24-T unconjugated
anti-Complement Component C4d (C4d) antibodyC4d 适用: 人 ELISA, IF, Coat, IHC (f) 宿主: 小鼠 Monoclonal C4D204 unconjugated
anti-Complement Component C4d (C4d) (AA 958-1335) antibodyC4d 适用: 人 IHC, WB, IP, ICC 宿主: 小鼠 Monoclonal D2 unconjugated
anti-Complement Component C4d (C4d) (AA 958-1335) antibodyC4d 适用: 人 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Complement Component C4d (C4d) (AA 1241-1256) antibodyC4d 适用: 人 IF, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Complement Component C4d (C4d) antibodyCarrier-free C4d 适用: 人 ELISA, IHC (p) 宿主: 小鼠 Monoclonal C4D204 unconjugated
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应用备注
- Immunohistology - Frozen, ELISA (dilution: 1/250, 1/600), Immunofluorescence, Immunohistology - Paraffin, Western Blotting
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限制
- 仅限研究用
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浓度
- IgG concentration 1.0 mg/ml
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缓冲液
- Borate buffered saline pH 8.4
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- -20°C
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- Complement C4d (C4d) (Complement Component C4d (C4d))
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别名
- C4d
抗原
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