This 14 AA human MCR42 immunogenic peptide sequence is 100 % identical in monkey, pig, & bovine, 84 % with mouse, and 69 % homologous with rat MC4-R. No significant sequence homology of MCR42 is seen with other melanocortin receptors.
纯化方法
Affinity chromatography purified
免疫原
MC4 R antibody was raised in rabbit using a 14 amino acid peptide of human MC4-R as the immunogen.
Melanocortin receptor 4 is a protein that in humans is encoded by the MC4R gene. It encodes the MC4 protein, a G-protein coupled receptor that binds alpha-melanocyte stimulating hormone ( alpha-MSH). In murine models MC4 receptors have been found to be involved in feeding behaviour, the regulation of metabolism, sexual behaviour, and male erectile function.