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APP 抗体 (Middle Region)

APP 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN634767
发货至: 中国
  • 抗原 See all APP 抗体
    APP (Amyloid beta (A4) Precursor Protein (APP))
    抗原表位
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    Middle Region
    适用
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    人, 小鼠, 大鼠
    宿主
    • 237
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    • 5
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    克隆类型
    • 257
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    多克隆
    标记
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    This APP antibody is un-conjugated
    应用范围
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    Western Blotting (WB)
    特异性
    APP antibody was raised against the middle region of APP
    纯化方法
    Affinity purified
    免疫原
    APP antibody was raised using the middle region of APP corresponding to a region with amino acids RMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYG
    Top Product
    Discover our top product APP Primary Antibody
  • 应用备注
    WB: 1 µg/mL
    Optimal conditions should be determined by the investigator.
    说明

    APP Blocking Peptide, catalog no. 33R-8067, is also available for use as a blocking control in assays to test for specificity of this APP antibody

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Lyophilized powder. Add distilled water for a 1 mg/mL concentration of APP antibody in PBS
    浓度
    Lot specific
    缓冲液
    PBS
    注意事项
    Avoid repeated freeze/thaw cycles.
    Dilute only prior to immediate use.
    储存条件
    4 °C/-20 °C
    储存方法
    Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.
  • 抗原
    APP (Amyloid beta (A4) Precursor Protein (APP))
    别名
    APP (APP 产品)
    背景
    APP is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
    分子量
    85 kDa (MW of target protein)
    途径
    Caspase Cascade in Apoptosis, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour
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