IREB2 抗体 (Middle Region)
Quick Overview for IREB2 抗体 (Middle Region) (ABIN633564)
抗原
See all IREB2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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特异性
- IREB2 antibody was raised against the middle region of IREB2
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纯化方法
- Affinity purified
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免疫原
- IREB2 antibody was raised using the middle region of IREB2 corresponding to a region with amino acids IQINLNSIVPSVSGPKRPQDRVAVTDMKSDFQACLNEKVGFKGFQIAAEK
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应用备注
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WB: 1 µg/mL
Optimal conditions should be determined by the investigator. -
说明
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IREB2 Blocking Peptide, catalog no. 33R-4113, is also available for use as a blocking control in assays to test for specificity of this IREB2 antibody
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Lyophilized powder. Add distilled water for a 1 mg/mL concentration of IREB2 antibody in PBS
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浓度
- Lot specific
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缓冲液
- PBS
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注意事项
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Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use. -
储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.
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- IREB2 (Iron-Responsive Element Binding Protein 2 (IREB2))
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别名
- IREB2
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背景
- IREB2 binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. IREB2 binds to the IRE element in ferritin which results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
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分子量
- 105 kDa (MW of target protein)
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途径
- Transition Metal Ion Homeostasis
抗原
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