DNMT3B 抗体
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北京 101111
Quick Overview for DNMT3B 抗体 (ABIN630856)
抗原
See all DNMT3B 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- Affinity purified
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免疫原
- DNMT3 B antibody was raised using a synthetic peptide corresponding to a region with amino acids GTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLEC
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应用备注
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WB: 1 µg/mL
Optimal conditions should be determined by the investigator. -
说明
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DNMT3B Blocking Peptide, (ABIN938993), is also available for use as a blocking control in assays to test for specificity of this DNMT3B antibody
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Lyophilized powder. Add distilled water for a 1 mg/mL concentration of DNMT0 antibody in PBS
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浓度
- Lot specific
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缓冲液
- PBS
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注意事项
- Avoid repeated freeze/thaw cycles.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.
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- DNMT3B (DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B))
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别名
- DNMT3B
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背景
- DNMT3B is required for genome wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. DNMT3B may preferentially methylate nucleosomal DNA within the nucleosome core region. DNMT3B may function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. DNMT3B seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, DNMT3B is involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.
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分子量
- 86 kDa (MW of target protein)
抗原
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