RRM1 抗体 (N-Term)
Quick Overview for RRM1 抗体 (N-Term) (ABIN630191)
抗原
See all RRM1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- RRM1 antibody was raised against the N terminal of RRM1
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纯化方法
- Purified
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免疫原
- RRM1 antibody was raised using the N terminal of RRM1 corresponding to a region with amino acids ATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHL
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应用备注
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WB: 1.25 µg/mL
Optimal conditions should be determined by the investigator. -
说明
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RRM1 Blocking Peptide, (ABIN936944), is also available for use as a blocking control in assays to test for specificity of this RRM1 antibody
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Lyophilized powder. Add distilled water for a 1 mg/mL concentration of RRM1 antibody in PBS
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浓度
- Lot specific
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缓冲液
- PBS
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注意事项
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Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use. -
储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.
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- RRM1 (Ribonucleotide Reductase M1 (RRM1))
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别名
- RRM1
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背景
- RRM1 is one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. Its gene is located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. Its gene may play a role in malignancies and disease that involve this region.
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分子量
- 90 kDa (MW of target protein)
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途径
- Positive Regulation of Endopeptidase Activity
抗原
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