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NONO 抗体 (N-Term)

This anti-NONO antibody is a 兔 多克隆 antibody detecting NONO in WB. Suitable for 人, 小鼠, 大鼠 和 犬.
产品编号 ABIN629888
发货至: 中国

Quick Overview for NONO 抗体 (N-Term) (ABIN629888)

抗原

See all NONO 抗体
NONO (Non-POU Domain Containing, Octamer-Binding (NONO))

适用

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人, 小鼠, 大鼠, 犬

宿主

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克隆类型

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多克隆

标记

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This NONO antibody is un-conjugated

应用范围

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Western Blotting (WB)
  • 抗原表位

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    N-Term

    特异性

    NONO antibody was raised against the N terminal of NONO

    纯化方法

    Purified

    免疫原

    NONO antibody was raised using the N terminal of NONO corresponding to a region with amino acids KQNHTPRKHHQHHHQQQHHQQQQQQPPPPPIPANGQQASSQNEGLTIDLK
  • 应用备注

    WB: 1.25 µg/mL
    Optimal conditions should be determined by the investigator.

    说明

    NONO Blocking Peptide, catalog no. 33R-4610, is also available for use as a blocking control in assays to test for specificity of this NONO antibody

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Lyophilized powder. Add distilled water for a 1 mg/mL concentration of NONO antibody in PBS

    浓度

    Lot specific

    缓冲液

    PBS

    注意事项

    Avoid repeated freeze/thaw cycles.
    Dilute only prior to immediate use.

    储存条件

    4 °C/-20 °C

    储存方法

    Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.
  • 抗原

    NONO (Non-POU Domain Containing, Octamer-Binding (NONO))

    别名

    NONO

    背景

    NONO is DNA- and RNA binding protein, involved in several nuclear processes. It binds the conventional octamer sequence in double stranded DNA. It also binds single-stranded DNA and RNA at a site independent of the duplex site. It is involved in pre-mRNA splicing and interacts with U5 snRNA. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs, be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 and be involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription.

    分子量

    52 kDa (MW of target protein)
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