PAWR 抗体
Quick Overview for PAWR 抗体 (ABIN6298166)
抗原
See all PAWR 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Rabbit Anti-Prostate Apoptosis Response protein-4 Antibody,
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限制
- 仅限研究用
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C (short-term), -20°C (long-term)
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- PAWR (PRKC, Apoptosis, WT1, Regulator (PAWR))
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别名
- Prostate Apoptosis Response protein-4
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背景
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Target Description: Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down- regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.
Gene Symbol: PAWR
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基因ID
- 5074
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UniProt
- Q96IZ0
抗原
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