BUB1B 抗体
Quick Overview for BUB1B 抗体 (ABIN6298121)
抗原
See all BUB1B 抗体适用
宿主
克隆类型
标记
应用范围
-
-
原理
- Rabbit Anti-BUB1B Antibody,
-
-
-
-
限制
- 仅限研究用
-
-
-
储存条件
- 4 °C,-20 °C
-
储存方法
- 2-8°C (short-term), -20°C (long-term)
-
-
- BUB1B (Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B))
-
别名
- BUB1B
-
背景
-
Target Description: Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression.
Gene Symbol: BUB1B
-
基因ID
- 701
-
UniProt
- O60566
抗原
-