Cyclin D2 抗体
Quick Overview for Cyclin D2 抗体 (ABIN6298006)
抗原
See all Cyclin D2 (CCND2) 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Rabbit Anti-Cyclin D2 (Ab-280) Antibody,
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限制
- 仅限研究用
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C (short-term), -20°C (long-term)
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- Cyclin D2 (CCND2)
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别名
- Cyclin D2
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背景
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Target Description: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).
Gene Symbol: CCND2
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基因ID
- 894
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UniProt
- P30279
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途径
- Cell Division Cycle, Mitotic G1-G1/S Phases
抗原
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