USP5 抗体
Quick Overview for USP5 抗体 (ABIN6297889)
抗原
See all USP5 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Mouse Anti-USP5 Antibody
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免疫原
- This USP5 antibody is generated from a mouse immunized with a recombination protein from the human region of human USP5.
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限制
- 仅限研究用
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C (short-term), -20°C (long-term)
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- USP5 (Ubiquitin Specific Peptidase 5 (USP5))
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别名
- USP5
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背景
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Target Description: Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys- 63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
Gene Symbol: USP5
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基因ID
- 8078
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UniProt
- P45974
抗原
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