TLR4 抗体
Quick Overview for TLR4 抗体 (ABIN6297482)
抗原
See all TLR4 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Mouse anti-Human/Monkey/Pig/Dog/Rat/Guinea Pig TLR4 Antibody (Toll Like Receptor 4) [Sodium Azide Free]
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特异性
- Cell surface
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纯化方法
- Recombinant human protein was used as the immunogen for the TLR4 antibody.
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免疫原
- Recombinant human protein was used as the immunogen for the TLR4 antibody.
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应用备注
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Functional Activity (Order SAF formulation)
Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 1-2 μg/mL
Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT (1) -
限制
- 仅限研究用
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缓冲液
- In 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- TLR4 (Toll-Like Receptor 4 (TLR4))
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别名
- Toll-like receptor 4
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背景
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Target Description: This mAb reacts with human Toll-like receptor 2 (TLR4). It is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene Symbol: TLR4
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基因ID
- 7099
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UniProt
- O00206
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途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome, S100 Proteins
抗原
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