UBE2D1 抗体
Quick Overview for UBE2D1 抗体 (ABIN629731)
抗原
See all UBE2D1 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- Purified
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免疫原
- UBE2 D1 antibody was raised using a synthetic peptide corresponding to a region with amino acids SQWSPALTVSKVLLSICSLLCDPNPDDPLVPDIAQIYKSDKEKYNRHARE
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应用备注
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WB: 1.25 µg/mL
Optimal conditions should be determined by the investigator. -
说明
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UBE2D1 Blocking Peptide, (ABIN5616860), is also available for use as a blocking control in assays to test for specificity of this UBE2D1 antibody
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Lyophilized powder. Add distilled water for a 1 mg/mL concentration of UBE0 1 antibody in PBS
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浓度
- Lot specific
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缓冲液
- PBS
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注意事项
- Avoid repeated freeze/thaw cycles.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.
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- UBE2D1 (Ubiquitin-Conjugating Enzyme E2D 1 (UBE2D1))
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别名
- UBE2D1
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背景
- The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2D1 is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases.
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分子量
- 16 kDa (MW of target protein)
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途径
- Activation of Innate immune Response, Toll-Like Receptors Cascades
抗原
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