Intestinal Alkaline Phosphatase 抗体
Quick Overview for Intestinal Alkaline Phosphatase 抗体 (ABIN6297135)
抗原
See all Intestinal Alkaline Phosphatase (ALPI) 抗体适用
宿主
克隆类型
标记
应用范围
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原理
 - Mouse anti-Human Alkaline Phosphatase Antibody (tissue-nonspecific) [IHC only]
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特异性
 - Cell surface, cytoplasmic
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纯化方法
 - Recombinant human ALPL protein was used as the immunogen for the tissue-nonspecific Alkaline Phosphatase antibody.
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免疫原
 - Recombinant human ALPL protein was used as the immunogen for the tissue-nonspecific Alkaline Phosphatase antibody.
 
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应用备注
 - Prediluted format : incubate for 30 min at RT (1)
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限制
 - 仅限研究用
 
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缓冲液
 - Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide, For IHC use only
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储存液
 - Sodium azide
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注意事项
 - This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
 - 4 °C,-20 °C
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储存方法
 - 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
 
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- Intestinal Alkaline Phosphatase (ALPI)
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别名
 - Intestinal-type alkaline phosphatase
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背景
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Target Description: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization, however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypo-phosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.
Gene Symbol: ALPI
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基因ID
 - 248
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UniProt
 - P09923
 
抗原
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