LHB 抗体
Quick Overview for LHB 抗体 (ABIN6296910)
抗原
See all LHB 抗体适用
宿主
克隆类型
标记
应用范围
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原理
 - Mouse anti-Human Luteinizing Hormone beta Antibody [Sodium Azide Free]
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特异性
 - Cytoplasmic, secreted
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纯化方法
 - Recombinant beta sub-unit of human LH was used as the immunogen for the Luteinizing Hormone beta antibody.
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免疫原
 - Recombinant beta sub-unit of human LH was used as the immunogen for the Luteinizing Hormone beta antibody.
 
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应用备注
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                        Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 1-2 μg/mL
Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min RT (1) - 
                                            
限制
 - 仅限研究用
 
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缓冲液
 - In 1X PBS, BSA free, sodium azide free
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储存液
 - Azide free
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储存条件
 - 4 °C,-20 °C
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储存方法
 - 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
 
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- LHB (Luteinizing Hormone beta Polypeptide (LHB))
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别名
 - Lutropin subunit beta
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物质类
 - Hormone
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背景
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Target Description: Luteinizing hormone (LH) is a glycoprotein. Each monomeric unit is a sugar-like protein molecule, two of these make the full, functional protein. Its structure is similar to the other glycoproteins, follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), and human chorionic gonadotropin (hCG). The protein dimer contains 2 polypeptide units, labeled alpha and beta subunits that are connected by two bridges. The alpha subunits of LH, FSH, TSH, and hCG are identical, and contain 92 amino acids. The beta subunits vary. LH has a beta subunit of 121 amino acids (LHB) that confers its specific biologic action and is responsible for interaction with the LH receptor. This beta subunit contains the same amino acids in sequence as the beta subunit of hCG and both stimulate the same receptor, however, the hCG beta subunit contains an additional 24 amino acids and the hormones differ in the composition of their sugar moieties. LH is synthesized and secreted by gonadotrophs in the anterior lobe of the pituitary gland. In concert with the other pituitary gonadotropin follicle-stimulating hormone (FSH), it is necessary for proper reproductive function. In the female, an acute rise of LH levels triggers ovulation. In the male, where LH has also been called Interstitial Cell-Stimulating Hormone (ICSH), it stimulates Leydig cell production of testosterone. LH is a useful marker in classification of pituitary tumors and the study of pituitary disease.
Gene Symbol: LHB
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基因ID
 - 3972
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UniProt
 - P01229
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途径
 - Metabolism of Steroid Hormones and Vitamin D, Peptide Hormone Metabolism, Hormone Activity, C21-Steroid Hormone Metabolic Process
 
抗原
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