HLA-B27 抗体
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Quick Overview for HLA-B27 抗体 (ABIN6296687)
抗原
See all HLA-B27 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Mouse anti-Human HLA-B Antibody [Sodium Azide Free]
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特异性
- Cell surface
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纯化方法
- Lymphocytes from an HLA-B27 patient were used as the immunogen for the HLA-B antibody.
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免疫原
- Lymphocytes from an HLA-B27 patient were used as the immunogen for the HLA-B antibody.
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应用备注
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Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 0.5-1 μg/mL -
限制
- 仅限研究用
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缓冲液
- In 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- HLA-B27 (HLA Class I Histocompatibility Antigen, B-27 alpha Chain (HLA-B27))
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别名
- HLA class I histocompatibility antigen, B-27 alpha chain
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背景
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Target Description: This mAb recognizes the HLA-B27 cell surface antigen on human cells. It may be used to HLA type human lymphocytes. Approximately 60 % of patients with ankylosing spondylitis are HLA-B27 positive. This reagent can be used to help identify this HLA haplotype in human lymphocytes. Major histocompatibility complex (MHC) molecules form an integral part of the immune response system. They are cell-surface receptors that bind pep- tides and present them to T lymphocytes. Human leukocyte antigens (HLAs) are polymorphic members of the MHC family that are specifically involved in the presentation of antigens to the T cell receptor. There are two classes of HLA antigens: class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). Class I molecules are expressed in nearly all cells and play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes. HLA-B encodes a membrane anchored heavy chain, which hetero-dimerizes with a light chain (b-2-Microglobulin) to form MHC-I. Polymorphisms yield hundreds of HLA-B alleles. The HLA-B27 allele appears with increased frequency in uveitis patients.
Gene Symbol: HLA-B///HLAB
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UniProt
- P03989
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途径
- Human Leukocyte Antigen (HLA) in Adaptive Immune Response
抗原
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