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ACTN2 抗体 (C-Term)

This anti-ACTN2 antibody is a 兔 多克隆 antibody detecting ACTN2 in WB 和 IHC. Suitable for 人, 小鼠, 大鼠 和 犬. This Primary Antibody has been cited in 1 publication.
产品编号 ABIN629641
发货至: 中国

Quick Overview for ACTN2 抗体 (C-Term) (ABIN629641)

抗原

See all ACTN2 抗体
ACTN2 (Actinin, alpha 2 (ACTN2))

适用

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人, 小鼠, 大鼠, 犬

宿主

  • 80
  • 62

克隆类型

  • 75
  • 67
多克隆

标记

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  • 2
  • 1
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  • 1
  • 1
  • 1
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  • 1
This ACTN2 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC)
  • 抗原表位

    • 57
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    • 1
    C-Term

    特异性

    Alpha Actinin 2 antibody was raised against the C terminal of ACTN2

    纯化方法

    Purified

    免疫原

    alpha Actinin 2 antibody was raised using the C terminal of ACTN2 corresponding to a region with amino acids VIASFRILASDKPYILAEELRRELPPDQAQYCIKRMPAYSGPGSVPGALD
  • 应用备注

    WB: 1.25 µg/mL, IHC: 4-8 µg/mL
    Optimal conditions should be determined by the investigator.

    说明

    Alpha Actinin 2 Blocking Peptide, (ABIN5612032), is also available for use as a blocking control in assays to test for specificity of this Alpha Actinin 2 antibody

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Lyophilized powder. Add distilled water for a 1 mg/mL concentration of ACTN2 antibody in PBS

    浓度

    Lot specific

    缓冲液

    PBS

    注意事项

    Avoid repeated freeze/thaw cycles.
    Dilute only prior to immediate use.

    储存条件

    4 °C/-20 °C

    储存方法

    Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.
  • Chopra, Kutys, Zhang, Polacheck, Sheng, Luu, Eyckmans, Hinson, Seidman, Seidman, Chen: "Force Generation via β-Cardiac Myosin, Titin, and α-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions." in: Developmental cell, Vol. 44, Issue 1, pp. 87-96.e5, (2018) (PubMed).

  • 抗原

    ACTN2 (Actinin, alpha 2 (ACTN2))

    别名

    alpha Actinin 2

    背景

    The alpha-actinins are a multigene family of four actin-binding proteins related to dystrophin. The two skeletal muscle isoforms of alpha-actinin (ACTN2 and ACTN3) are major structural components of the Z-line involved in anchoring the actin-containing thin filaments. In humans, ACTN2 is expressed in all muscle fibres, while ACTN3 expression is restricted to a subset of type 2 fibres. Murine Actn2 and Actn3 are differentially expressed, spatially and temporally, during embryonic development and, in contrast to humans, alpha-actinin-2 expression does not completely overlap alpha-actinin-3 in postnatal skeletal muscle, suggesting independent function.

    分子量

    98 kDa (MW of target protein)

    途径

    Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Negative Regulation of Transporter Activity
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