FSHR 抗体
Quick Overview for FSHR 抗体 (ABIN6296013)
抗原
See all FSHR 抗体适用
宿主
克隆类型
标记
应用范围
- 
    
- 
                                            
原理
 - Mouse anti-Human FSH Receptor Antibody [Sodium Azide Free]
 - 
                                            
特异性
 - Cytoplasmic, cell surface
 - 
                                            
纯化方法
 - A human recombinant protein was used as the immunogen for this FSHR antibody.
 - 
                                            
免疫原
 - A human recombinant protein was used as the immunogen for this FSHR antibody.
 
 - 
                                            
 - 
    
 - 
    
- 
                                            
应用备注
 - 
                        FACS: 0.5-1 μg/10^6 cells
IF: 1-2 μg/mL
IHC (FFPE): 1-2 μg/mL for 30 min at RT - 
                                            
限制
 - 仅限研究用
 
 - 
                                            
 - 
    
- 
                                            
缓冲液
 - In 1X PBS, BSA free, sodium azide free
 - 
                                            
储存液
 - Azide free
 - 
                                            
储存条件
 - 4 °C,-20 °C
 - 
                                            
储存方法
 - 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
 
 - 
                                            
 - 
    
- FSHR (Follicle Stimulating Hormone Receptor (FSHR))
 - 
                                            
别名
 - Follicle-stimulating hormone receptor
 - 
                                            
背景
 - 
                        
Target Description: Follicle-stimulating hormone receptor (FSHR) is a 695 amino acid G protein coupled receptor. FSH binds to the receptor in a hand-clasp fashion via its alpha and beta subunits. While the alpha subunit of FSH is involved in the binding of FSH to the receptor, the beta subunit stabilizes this interaction. Linkage studies suggest that a missense mutation in the FSHR gene can cause reduced FSH binding affinity and lead to a condition known as hypergonadotropic ovarian dysgenesis (ODG). In males however, this mutation does not appear to have a detrimental affect on fertility. It is believed that a mutation in the FSHR gene is also associated with ovarian hyperstimulation syndrome, a condition characterized by the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells.
Gene Symbol: FSHR///LGR1
 - 
                                            
基因ID
 - 2492
 - 
                                            
UniProt
 - P23945
 - 
                                            
途径
 - Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Platelet-derived growth Factor Receptor Signaling
 
抗原
 -