PROX1 抗体 (N-Term)
Quick Overview for PROX1 抗体 (N-Term) (ABIN6295646)
抗原
See all PROX1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 144-175, N-Term
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原理
- Rabbit Anti-PROX1 (N-term) Antibody
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免疫原
- This PROX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 144-175 amino acids from the N-terminal region of human PROX1.
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anti-Prospero Homeobox 1 (PROX1) (AA 638-737) antibody
PROX1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1H6 unconjugated
anti-Prospero Homeobox 1 (PROX1) (AA 492-522) antibodyPROX1 适用: 人, 大鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Prospero Homeobox 1 (PROX1) (AA 492-520) antibodyPROX1 适用: 人, 小鼠 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Prospero Homeobox 1 (PROX1) (AA 185-214) antibodyPROX1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Prospero Homeobox 1 (PROX1) (AA 638-737) antibodyPROX1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1E7 unconjugated
anti-Prospero Homeobox 1 (PROX1) (Center) antibodyPROX1 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Prospero Homeobox 1 (PROX1) (AA 444-478) antibodyPROX1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB51404 unconjugated
anti-Prospero Homeobox 1 (PROX1) (AA 1-300) antibodyPROX1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Prospero Homeobox 1 (PROX1) (AA 547-737) antibodyPROX1 适用: 人, 马, Avian WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Prospero Homeobox 1 (PROX1) antibodyPROX1 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
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限制
- 仅限研究用
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C (short-term), -20°C (long-term)
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- PROX1 (Prospero Homeobox 1 (PROX1))
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别名
- PROX1
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背景
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Target Description: The expression pattern of the Prox1 homeo box gene suggests that it has a role in a variety of embryonic tissues, including lens. Analysis of mRNA reveals that Prox mRNA is present in many different human tissues and that lens demonstrated the highest level. Homozygous Prox1-null mice die at midgestation from multiple developmental defects, and a targeted effect on lens development has been reported. Prox1 inactivation caused abnormal cellular proliferation, downregulated expression of the cell cycle inhibitors Cdkn1b and Cdkn1c, misexpression of E-cadherin, and excessive apoptosis. Consequently, mutant lens cells failed to polarize and elongate properly, resulting in a hollow lens. The Prox1 gene is expressed in a subpopulation of endothelial cells that by budding and sprouting give rise to the lymphatic system. Prox1 appears to be a specific and required regulator of the development of the lymphatic system. Prox1 also has been document to be required for hepatocyte migration in the mouse. Loss of Prox1 results in a smaller liver with a reduced population of clustered hepatocytes. The homeodomain protein Prox1 regulates the egress of progenitor cells from the cell cycle in the embryonic mouse retina. Cells lacking Prox1 are less likely to stop dividing, and ectopic expression of Prox1 forces progenitor cells to exit the cell cycle. Prox1 acts as a key participant in progenitor-cell proliferation and cell-fate determination in the vertebrate retina.
Gene Symbol: PROX1
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基因ID
- 5629
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UniProt
- Q92786
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途径
- Stem Cell Maintenance, Regulation of Muscle Cell Differentiation
抗原
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