Desmocollin 2 抗体 (Extracellular Domain)
Quick Overview for Desmocollin 2 抗体 (Extracellular Domain) (ABIN6295454)
抗原
See all Desmocollin 2 (DSC2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Extracellular Domain
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原理
- Mouse anti-Human/Mouse/Rat Desmocollin 2/3 Antibody [Sodium Azide Free]
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特异性
- Cell surface
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纯化方法
- A recombinant protein corresponding to the extracellular domain of human Desmocollin 2 was used as the immunogen for the Desmocollin 2/3 antibody.
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免疫原
- A recombinant protein corresponding to the extracellular domain of human Desmocollin 2 was used as the immunogen for the Desmocollin 2/3 antibody.
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应用备注
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WB: 0.5-1 μg/mL
FACS: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 1-2 μg/mL
Immunohistochemistry (FFPE): 1-2 μg/mL for 30 min at RT -
限制
- 仅限研究用
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缓冲液
- In 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- Desmocollin 2 (DSC2)
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别名
- Desmocollin-2
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背景
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Target Description: Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. The desmosome is subdivided into two regions. The plaque region lies adjacent to the plasma, and is believed to contain molecules that attach the intermediate filament cytoskeleton to the desmosome. The core region is composed of transmembrane glycoproteins that are thought to mediate cell-cell adhesion. Desmogleins and desmocollins are the main desmosomal transmembrane proteins. These desmosomal glycoproteins belong to the members of the cadherin family of adhesion molecules. Three different isoforms of both desmogleins and desmocollins have been identified, named as desmoglein 1-3 and desmocollins. Desmosomal cadherins showed differentiation-specific expression in the human epidermis, although the functional significance of this differential expression is not fully understood. Desmocollin-1 can be found in the upper layers. The expression of Desmocollin-2 varies in the basal and suprabasal layers. And Desmocollin-3 is expressed more evenly throughout the suprabasal layers.
Gene Symbol: DSC2///CDHF2///DSC3
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基因ID
- 1824
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UniProt
- Q02487
抗原
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