ESR2 抗体 (C-Term)
Quick Overview for ESR2 抗体 (C-Term) (ABIN6294672)
抗原
See all ESR2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- Mouse anti-Human/Monkey/Mouse/Rat/Pig/Horse/Sheep Estrogen Receptor beta Antibody [Sodium Azide Free]
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特异性
- Predominantly nuclear
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纯化方法
- The C-terminus fragment of recombinant human Estrogen Receptor beta protein was used as the immunogen for this antibody.
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免疫原
- The C-terminus fragment of recombinant human Estrogen Receptor beta protein was used as the immunogen for this antibody.
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应用备注
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FACS: 0.5-1 μg/10e6 cells
IF: 1-2 μg/mL
WB: 0.5-1 μg/mL
IHC (FFPE): 0.5-1 μg/mL for 30 minutes at RT (1) -
限制
- 仅限研究用
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缓冲液
- In 1X PBS ( pH 7.4), BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- ESR2 (Estrogen Receptor 2 (ESR2))
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别名
- Estrogen receptor beta
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背景
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Target Description: Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including alpha and beta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ER alpha and beta are differentially activated by various ligands. Ligand interaction triggers a cascade of events, including dissociation from heat shock proteins, recepter dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER alpha and beta may be regulated by distinct mechanisms even though they share many functional characteristics.
Gene Symbol: ESR2///ESTRB///NR3A2
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基因ID
- 2100
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UniProt
- Q92731
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途径
- Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling
抗原
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