TFF1 抗体 (C-Term)
Quick Overview for TFF1 抗体 (C-Term) (ABIN6294640)
抗原
See all TFF1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- Mouse anti-Human/Monkey TFF1 Antibody [Sodium Azide Free]
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特异性
- Cytoplasmic
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纯化方法
- A C-terminus peptide was used as the immunogen for the TFF1 antibody.
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免疫原
- A C-terminus peptide was used as the immunogen for the TFF1 antibody.
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应用备注
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Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 0.5-1 μg/mL
Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT (1)
Prediluted format: incubate for 30 min at RT (2) -
限制
- 仅限研究用
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缓冲液
- In 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- TFF1 (Trefoil Factor 1 (TFF1))
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别名
- Trefoil factor 1
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背景
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Target Description: It recognizes a polypeptide of 6.5 kDa, identified as pS2 estrogen-regulated protein. Its epitope is located in the c-terminus of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60 % of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy.
Gene Symbol: TFF1///BCEI///PS2
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基因ID
- 7031
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UniProt
- P04155
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途径
- EGFR Signaling Pathway
抗原
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