KRT15 抗体 (C-Term)
Quick Overview for KRT15 抗体 (C-Term) (ABIN6294627)
抗原
See all KRT15 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- Mouse anti-Human/Rat/Cow Cytokeratin 15 Antibody [Sodium Azide Free]
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特异性
- Cytoplasmic
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纯化方法
- A 17 amino acid sequence from the C- terminal of human CK15 was used as the immunogen for the Keratin 15 antibody.
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免疫原
- A 17 amino acid sequence from the C- terminal of human CK15 was used as the immunogen for the Keratin 15 antibody.
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应用备注
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Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 1-2 μg/mL
WB: 0.5-1 μg/mL
Immunohistochemistry (FFPE & Frozen): 0.5-1 μg/mL for 30 min at RT -
限制
- 仅限研究用
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缓冲液
- In 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- KRT15 (Keratin 15 (KRT15))
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别名
- Keratin, type I cytoskeletal 15
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背景
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Target Description: Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratin 15 is a type I keratin which is expressed only in basal keratinocytes in stratified epithelia and does not appear to have a natural type II expression partner. Keratin 15 is down regulated in activated keratinocytes. Cytokeratin 15 is a specific marker of stem cells of the hair-follicle bulge and may be a useful marker for diagnosis between basal cell carcinoma (BCC) and trichoepithelioma. Trichoblastoma are benign neoplasms of follicular differentiation frequently found in nevus sebaceous. Many morphologic features are shared with nodular basal cell carcinoma, sometimes rendering a diagnosis difficult. Trichoblastoma and BCC show variable expression of Cytokeratin 15 and Cytokeratin 19, and absence of hair keratins.
Gene Symbol: KRT15///KRTB
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基因ID
- 3866
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UniProt
- P19012
抗原
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