MALT1 抗体 (AA 701-808)
Quick Overview for MALT1 抗体 (AA 701-808) (ABIN6294577)
抗原
See all MALT1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 701-808
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原理
- Mouse anti-Human MALT1 Antibody [Sodium Azide Free]
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特异性
- Cytoplasmic
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纯化方法
- A recombinant fragment (aa 701-808) was used as the immunogen for this antibody.
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免疫原
- A recombinant fragment (aa 701-808) was used as the immunogen for this antibody.
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应用备注
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FACS: 0.5-1 μg/million cells
IF: 1-2 μg/mL
WB: 0.5-1 μg/mL
IHC (FFPE): 0.5-1 μg/mL for 30 minutes at RT (1)
Prediluted format: incubate for 30 min at RT (2) -
限制
- 仅限研究用
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缓冲液
- In 1X PBS ( pH 7.4), BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- MALT1 (Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 1 (MALT1))
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别名
- Mucosa-associated lymphoid tissue lymphoma translocation protein 1
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背景
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Target Description: Mucosa associated lymphoid tissue lymphoma translocation gene 1 is found in extranodal low-grade B cell lymphomas. It encodes two Ig-like C2-type domains and fuses with an API2 gene, which is highly expressed in adult lymphoid tissue. The translocation of the MALT1 gene, which maps to human chromosome 18q21, and the apoptosis-inhibiting API2 gene results in an increased development of MALT lymphomas and apoptosis inhibition. Sites at which this API2-MALT1 (11,18)(q21,q21) translocation commonly occurs are within human lung and kidney tissue. MALT lymphoma expresses nuclear < a href=../search_result.php?search_txt=bcl10>Bcl10, which mediates the oligomerization and activation of a caspase-like domain. MALT1 mRNA is found in pre-B cells, mature B cells and plasma cells.
Gene Symbol: MALT1///MLT
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基因ID
- 10892
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UniProt
- Q9UDY8
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途径
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins
抗原
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