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AIRE 抗体 (Internal Region)

Name: AIRE 抗体 (Internal Region)
SKU: ABIN6266320
Availability: OutOfStock

This anti-AIRE antibody is a 兔多克隆 antibody detecting AIRE in WB, ELISA, IF, IHC 和 ICC. Suitable for 人, 小鼠和大鼠.

Western blot analysis of Hela whole cell lysates, using AIRE Antibody. (AIRE 抗体 (Internal Region))

IF/ICC

ABIN6276866 at 1/100 staining Mouse testis tissue by IHC-P. (AIRE 抗体 (Internal Region))

IHC

3 images

产品编号 ABIN6266320

发货至: 中国

Quick Overview for AIRE 抗体 (Internal Region) (ABIN6266320)

抗原

See all AIRE 抗体

AIRE (Autoimmune Regulator (AIRE))

适用

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This AIRE antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Discover our top product AIRE Primary Antibody

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Internal Region

特异性

AIRE Antibody detects endogenous levels of total AIRE.

纯化方法

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

免疫原

A synthesized peptide derived from human AIRE, corresponding to a region within the internal amino acids.

亚型

IgG
anti-Autoimmune Regulator (AIRE) (C-Term) antibody
Verified AIRE 适用: 人 WB, ELISA, IF, IHC, FACS 宿主: 山羊 Polyclonal unconjugated

anti-Autoimmune Regulator (AIRE) (AA 30-130) antibody
AIRE 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Autoimmune Regulator (AIRE) (N-Term) antibody
AIRE 适用: 人, 小鼠, 大鼠, 犬, 马, Cow, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Autoimmune Regulator (AIRE) (Internal Region) antibody
Verified AIRE 适用: 人, Pig WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated

anti-Autoimmune Regulator (AIRE) (AA 39-108) antibody
AIRE 适用: 人 ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated

anti-Autoimmune Regulator (AIRE) (pSer156) antibody
AIRE 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Autoimmune Regulator (AIRE) (N-Term) antibody
AIRE 适用: 人, 小鼠, 大鼠, 犬, 马, 豚鼠, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Autoimmune Regulator (AIRE) (AA 76-125) antibody
AIRE 适用: 人, 马, Cow, 猴 WB 宿主: 兔 Polyclonal unconjugated

anti-Autoimmune Regulator (AIRE) (Internal Region) antibody
Verified AIRE 适用: 人, 小鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated

anti-Autoimmune Regulator (AIRE) (AA 467-516) antibody
AIRE 适用: 人, 猴 WB 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
抗原

AIRE (Autoimmune Regulator (AIRE))

别名

AIRE

背景

Description: Transcription factor playing an essential role to promote self-tolerance in the thymus by regulating the expression of a wide array of self-antigens that have the commonality of being tissue-restricted in their expression pattern in the periphery, called tissue restricted antigens (TRA) (PubMed:26084028). Binds to G-doublets in an A/T-rich environment, the preferred motif is a tandem repeat of 5'-ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Mainly expressed by medullary thymic epithelial cells (mTECs), induces the expression of thousands of tissue-restricted proteins, which are presented on major histocompatibility complex class I (MHC-I) and MHC-II molecules to developing T-cells percolating through the thymic medulla (PubMed:26084028). Also induces self-tolerance through other mechanisms such as the regulation of the mTEC differentiation program. Controls the medullary accumulation of thymic dendritic cells and the development of regulatory T-cell through the regulation of XCL1 expression. Regulates the production of CCR4 and CCR7 ligands in medullary thymic epithelial cells and alters the coordinated maturation and migration of thymocytes. In thimic B-cells, allows the presentation of licensing-dependent endogenous self-anitgen for negative selection. In secondary lymphoid organs, induces functional inactivation of CD4+ T-cells. Expressed by a distinct bone marrow-derived population, induces self-tolerance through a mechanism that does not require regulatory T-cells and is resitant to innate inflammatory stimuli (By similarity).
Gene: AIRE

分子量

58kDa

基因ID

326

UniProt

O43918

途径

Chromatin Binding