TSC1 抗体 (C-Term)
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Quick Overview for TSC1 抗体 (C-Term) (ABIN6265766)
抗原
See all TSC1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- TSC1 Antibody detects endogenous levels of total TSC1.
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预测反应
- Horse,Sheep,Dog
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human TSC1, corresponding to a region within C-terminal amino acids.
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亚型
- IgG
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anti-Tuberous Sclerosis 1 (TSC1) (AA 550-650) antibody
TSC1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tuberous Sclerosis 1 (TSC1) (AA 836-1164) antibodyTSC1 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 3A2 unconjugated
anti-Tuberous Sclerosis 1 (TSC1) (AA 836-1164) antibodyTSC1 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 5A8 unconjugated
anti-Tuberous Sclerosis 1 (TSC1) antibodyTSC1 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tuberous Sclerosis 1 (TSC1) (AA 401-430) antibodyTSC1 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tuberous Sclerosis 1 (TSC1) (C-Term) antibodyTSC1 适用: 人, 小鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Tuberous Sclerosis 1 (TSC1) (pSer505) antibodyTSC1 适用: 人, 小鼠, 绵羊 ELISA, WB, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Tuberous Sclerosis 1 (TSC1) (AA 101-344) antibodyTSC1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tuberous Sclerosis 1 (TSC1) (AA 401-430) antibodyTSC1 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB11648 unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- TSC1 (Tuberous Sclerosis 1 (TSC1))
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别名
- TSC1
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背景
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Description: In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:12271141, PubMed:28215400). Seems not to be required for TSC2 GAP activity towards RHEB (PubMed:15340059). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity). Acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155).
Gene: TSC1
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分子量
- 150 kDa
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基因ID
- 7248
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UniProt
- Q92574
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途径
- RTK signaling, AMPK Signaling, Regulation of Cell Size, Tube Formation
抗原
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