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TBK1 抗体 (Internal Region)

Name: TBK1 抗体 (Internal Region)
SKU: ABIN6265480
Availability: OutOfStock

This anti-TBK1 antibody is a 兔多克隆 antibody detecting TBK1 in WB, ELISA, IHC, IF 和 ICC. Suitable for 人, 小鼠和大鼠.

Western blot analysis of Hela whole cell lysates, using TBK1 Antibody. (TBK1 抗体 (Internal Region))

ABIN6277285 at 1/100 staining Human gastric tissue by IHC-P. (TBK1 抗体 (Internal Region))

IHC

2 images

产品编号 ABIN6265480

发货至: 中国

Quick Overview for TBK1 抗体 (Internal Region) (ABIN6265480)

抗原

See all TBK1 抗体

TBK1 (TANK-Binding Kinase 1 (TBK1))

适用

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This TBK1 antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Discover our top product TBK1 Primary Antibody

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Internal Region

特异性

TBK1 Antibody detects endogenous levels of total TBK1.

预测反应

Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

纯化方法

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

免疫原

A synthesized peptide derived from human TBK1, corresponding to a region within the internal amino acids.

亚型

IgG
anti-TANK-Binding Kinase 1 (TBK1) (AA 440-729) antibody
TBK1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-TANK-Binding Kinase 1 (TBK1) antibody
TBK1 适用: 人 WB, IP, IF 宿主: 兔 Monoclonal unconjugated

anti-TANK-Binding Kinase 1 (TBK1) (pSer172) antibody
TBK1 适用: 小鼠, 大鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated

anti-TANK-Binding Kinase 1 (TBK1) (AA 9-310) antibody
TBK1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-TANK-Binding Kinase 1 (TBK1) (AA 150-181) antibody
TBK1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB16573 unconjugated

anti-TANK-Binding Kinase 1 (TBK1) (AA 364-585) antibody
TBK1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-TANK-Binding Kinase 1 (TBK1) (C-Term) antibody
TBK1 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-TANK-Binding Kinase 1 (TBK1) (AA 644-661) antibody
TBK1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-TANK-Binding Kinase 1 (TBK1) (AA 74-123) antibody
TBK1 适用: 人, 小鼠, 大鼠, Cow, 兔, 犬, 猴, Pig, 马, 豚鼠, 斑马鱼, Hamster, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-TANK-Binding Kinase 1 (TBK1) (AA 539-588) antibody
TBK1 适用: 人, 小鼠, 大鼠, Cow, 兔, 犬, 猴, Pig, 马, 豚鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
抗原

TBK1 (TANK-Binding Kinase 1 (TBK1))

别名

TBK1

背景

Description: Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes. Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus. Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy (PubMed:21617041). Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (PubMed:27103069). Phosphorylates and activates AKT1 (PubMed:21464307). Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C (PubMed:21270402). Phosphorylates Borna disease virus (BDV) P protein (PubMed:16155125).
Gene: TBK1

分子量

84kDa

基因ID

29110

UniProt

Q9UHD2

途径

TLR signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, SARS-CoV-2 Protein Interactome