SYVN1 抗体 (Internal Region)
Quick Overview for SYVN1 抗体 (Internal Region) (ABIN6265416)
抗原
See all SYVN1 抗体适用
宿主
克隆类型
标记
应用范围
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    - 
                                            抗原表位
- Internal Region
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                                            特异性
- SYVN1 Antibody detects endogenous levels of total SYVN1.
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                                            预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog
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                                            纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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                                            免疫原
- A synthesized peptide derived from human SYVN1, corresponding to a region within the internal amino acids.
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                                            亚型
- IgG
 
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                                            应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
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                                            限制
- 仅限研究用
 
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                                            状态
- Liquid
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                                            浓度
- 1 mg/mL
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                                            缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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                                            储存液
- Sodium azide
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                                            注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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                                            储存条件
- -20 °C
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                                            储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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                                            有效期
- 12 months
 
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    - SYVN1 (Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1))
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                                            别名
- SYVN1
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                                            背景
- 
                        Description: Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130). Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130). Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation (PubMed:17141218). Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis (PubMed:17170702). Mediates the ubiquitination and subsequent degradation of cytoplasmic NFE2L1 (By similarity). Gene: SYVN1 
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                                            分子量
- 68-76 kDa
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                                            基因ID
- 84447
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                                            UniProt
- Q86TM6
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                                            途径
- ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling
 抗原
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