SUFUH 抗体 (N-Term)
Quick Overview for SUFUH 抗体 (N-Term) (ABIN6265364)
抗原
See all SUFUH 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- SUFU Antibody detects endogenous levels of total SUFU.
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预测反应
- Bovine,Horse,Dog,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human SUFU, corresponding to a region within N-terminal amino acids.
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亚型
- IgG
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anti-Suppressor of Fused Homolog (SUFUH) (AA 325-484) antibody
SUFUH 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Fused Homolog (SUFUH) (AA 433-484) antibodySUFUH 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Fused Homolog (SUFUH) (AA 325-484) antibodySUFUH 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Fused Homolog (SUFUH) (AA 308-341), (C-Term) antibodySUFUH 适用: 人 WB 宿主: 兔 Polyclonal RB53250 unconjugated
anti-Suppressor of Fused Homolog (SUFUH) antibodySUFUH 适用: 人, 小鼠, Green Monkey WB, IHC (p) 宿主: 小鼠 Monoclonal 1783CT536-263-29 unconjugated
anti-Suppressor of Fused Homolog (SUFUH) (C-Term) antibodySUFUH 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, 兔, Pig, Bat, 猴, 小鸡, 非洲爪蟾 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Fused Homolog (SUFUH) (AA 1-484) antibodySUFUH 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Fused Homolog (SUFUH) (AA 181-280) antibodySUFUH 适用: 人 ELISA, PLA 宿主: 小鼠 Monoclonal 1B2 unconjugated
anti-Suppressor of Fused Homolog (SUFUH) antibodySUFUH 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Fused Homolog (SUFUH) (Middle Region) antibodySUFUH 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, 兔, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- SUFUH (Suppressor of Fused Homolog (SUFUH))
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别名
- SUFU
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背景
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Description: Negative regulator in the hedgehog/smoothened signaling pathway. Down-regulates GLI1-mediated transactivation of target genes (PubMed:15367681, PubMed:24311597, PubMed:24217340). Down-regulates GLI2-mediated transactivation of target genes (PubMed:24311597, PubMed:24217340). Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein (PubMed:10806483, PubMed:24217340). Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A). Required for normal embryonic development. Required for the proper formation of hair follicles and the control of epidermal differentiation (By similarity).
Gene: SUFU
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分子量
- 54 kDa
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基因ID
- 51684
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UniProt
- Q9UMX1
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途径
- Hedgehog Signaling, Tube Formation, Maintenance of Protein Location
抗原
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